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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TRPC6 All Species: 22.42
Human Site: S589 Identified Species: 54.81
UniProt: Q9Y210 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y210 NP_004612.2 931 106326 S589 A R I K W D P S D P Q I I S E
Chimpanzee Pan troglodytes XP_508715 931 106398 S589 A R I K W D P S D P Q I I S E
Rhesus Macaque Macaca mulatta XP_001111979 862 99426 I555 V V L S F S R I A Y I L P A N
Dog Lupus familis XP_546553 1099 124087 S757 A R I K W D P S D P Q I I S E
Cat Felis silvestris
Mouse Mus musculus Q61143 930 106714 T588 A R I K W D P T D P Q I I S E
Rat Rattus norvegicus Q9JMI9 836 95664 L529 P Q I I S E G L Y A I A V V L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510377 989 112393 S647 A R I K W D P S D P Q I I S E
Chicken Gallus gallus XP_417184 895 102379 S579 A R I N W D P S D P Q I I S E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001025453 855 98053 N548 E H Y T D L T N V V L P F E V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34586 1027 118084 K631 T D V V E N H K I T Q W V G Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 69.8 80.2 N.A. 92.8 66.8 N.A. 83.9 85.7 N.A. 70.5 N.A. N.A. N.A. 32.9 N.A.
Protein Similarity: 100 99.5 79.4 82.5 N.A. 95.3 77.9 N.A. 89 91 N.A. 79.4 N.A. N.A. N.A. 53.2 N.A.
P-Site Identity: 100 100 0 100 N.A. 93.3 6.6 N.A. 100 93.3 N.A. 0 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 100 26.6 100 N.A. 100 26.6 N.A. 100 93.3 N.A. 6.6 N.A. N.A. N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 60 0 0 0 0 0 0 0 10 10 0 10 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 0 10 60 0 0 60 0 0 0 0 0 0 % D
% Glu: 10 0 0 0 10 10 0 0 0 0 0 0 0 10 60 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 0 0 10 0 0 % F
% Gly: 0 0 0 0 0 0 10 0 0 0 0 0 0 10 0 % G
% His: 0 10 0 0 0 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 70 10 0 0 0 10 10 0 20 60 60 0 0 % I
% Lys: 0 0 0 50 0 0 0 10 0 0 0 0 0 0 0 % K
% Leu: 0 0 10 0 0 10 0 10 0 0 10 10 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 10 0 10 0 10 0 0 0 0 0 0 10 % N
% Pro: 10 0 0 0 0 0 60 0 0 60 0 10 10 0 0 % P
% Gln: 0 10 0 0 0 0 0 0 0 0 70 0 0 0 10 % Q
% Arg: 0 60 0 0 0 0 10 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 10 10 10 0 50 0 0 0 0 0 60 0 % S
% Thr: 10 0 0 10 0 0 10 10 0 10 0 0 0 0 0 % T
% Val: 10 10 10 10 0 0 0 0 10 10 0 0 20 10 10 % V
% Trp: 0 0 0 0 60 0 0 0 0 0 0 10 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 10 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _